兩個不同的中國研究團隊研究結果指出,3位SARS-CoV-2病毒陽性的新生兒,可能是被新冠肺炎確診的母親,於懷孕時期胎內所感染;檢測結果是根據IgM免疫球蛋白的抗體量來決定;然而,目前利用血清中IgM抗體來偵測其他新生兒先天性疾病,例如先天性傷寒,敏感度和特異性均不高;加上目前是否能利用血清中IgM抗體來偵測SARS-CoV-2病毒抗原仍不清楚,正確性有待釐清;因此SARS-CoV-2病毒是否會垂直感染,有待更多來研究結果證實。

(財團法人國家衛生研究院 蔡慧如博士摘要整理)

Two articles reported in this issue of JAMA from separate research teams in China present details of 3 neonates who may have been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in utero from mothers with coronavirus disease 2019 (COVID-19).1,2 Evidence for such transmission is based on elevated IgM antibody values in blood drawn from the neonates following birth. All infants also had elevated IgG antibody values and cytokine levels, although these may have crossed the placenta from the mother to the infant. No infant specimen had a positive reverse transcriptase–polymerase chain reaction test result, so there is not virologic evidence for congenital infection in these cases to support the serologic suggestion of in utero transmission. Nevertheless, the serologic data are provocative for a virus that is believed to be spread by respiratory secretions and—given the modeling showing that a significant percentage of the world’s population, many of them pregnant women, will be infected over the next weeks or months—it is one that deserves careful consideration. However, at this time, these data are not conclusive and do not prove in utero transmission.

Author:Molly Szerlip, Saif Anwaruddin, Herbert D Aronow, et al.
原文連結:https://jamanetwork.com/journals/jama/fullarticle/2763851