作者認為Chloroquine /Hydroxychloroquine在其他病毒上沒有成功臨床案例,在SARS-CoV-1感染老鼠沒效果,COVID-19致病機轉不明情況下,治療病人可能會有害。

(財團法人國家衛生研究院 郭書辰醫師摘要整理)

TO THE EDITOR – We read with great interest the article by Yao X et al [1] reporting in vitro activity of Hydroxychloroquine (HCQ) in inhibiting severe acute respiratory syndrome coronavirus (SARS -CoV) -2. The authors suggest , on in -vitro experiment results base , an alternative HCQ dose regimen for future clinical trials while several clinical trials on chloroquine (CQ) and HCQ based regimen for Coronavirus Disease 2019 (COVID -19) are still ongoing [1].

Author:Maurizio Guastalegname, Alfredo Vallone
原文連結:https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa321/581141