本研究蒐集中國30省552間醫院1099名實驗室確診武漢肺炎病患資料。主要觀察點包括：加護病房收治、呼吸器使用、及死亡。本研究由中國國家衛健委IRB核准且不需病患同意函。所有個案中，5.0%由加護病房收治、2.3%使用呼吸器、1.4%死亡；僅1.9%有與野生動物接觸史；43.8%於醫院收治時已有發燒症狀，但88.7%於住院時發生發燒症狀；56.4%於住院時chest CT呈現纖維化。17.9%非重症及2.9%重症患者無法從chest CT上觀察到異常；83.2%病患於住院時有淋巴細胞減少之症狀。研究顯示，有些病患在疾病初期不會有發燒或chest CT可觀察到的病變。
(財團法人國家衛生研究院 莊淑鈞博士摘要整理)
BACKGROUND
Since December 2019, when coronavirus disease 2019 (Covid-19) emerged in Wuhan city and rapidly spread throughout China, data have been needed on the clinical characteristics of the affected patients.
METHODS
We extracted data regarding 1099 patients with laboratory-confirmed Covid-19 from 552 hospitals in 30 provinces, autonomous regions, and municipalities in mainland China through January 29, 2020. The primary composite end point was admission to an intensive care unit (ICU), the use of mechanical ventilation, or death.
RESULTS
The median age of the patients was 47 years; 41.9% of the patients were female. The primary composite end point occurred in 67 patients (6.1%), including 5.0% who were admitted to the ICU, 2.3% who underwent invasive mechanical ventilation, and 1.4% who died. Only 1.9% of the patients had a history of direct contact with wildlife. Among nonresidents of Wuhan, 72.3% had contact with residents of Wuhan, including 31.3% who had visited the city. The most common symptoms were fever (43.8% on admission and 88.7% during hospitalization) and cough (67.8%). Diarrhea was uncommon (3.8%). The median incubation period was 4 days (interquartile range, 2 to 7). On admission, ground-glass opacity was the most common radiologic finding on chest computed tomography (CT) (56.4%). No radiographic or CT abnormality was found in 157 of 877 patients (17.9%) with nonsevere disease and in 5 of 173 patients (2.9%) with severe disease. Lymphocytopenia was present in 83.2% of the patients on admission.
CONCLUSIONS
During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness. Patients often presented without fever, and many did not have abnormal radiologic findings. (Funded by the National Health Commission of China and others.)
Author：Wei-jie Guan, Zheng-yi Ni, Yu Hu, et al.
原文連結：https://www.nejm.org/doi/full/10.1056/NEJMoa2002032