個案1,60多歲女性,2020一月中旬自中國返美,一個星期之後,因肺炎住院,且武漢肺炎病毒檢測陽性。8天之後,個案的丈夫(個案2)病毒檢測陽性住院。個案2無中國旅遊史但與他的妻子有密切接觸。兩名個案共有372名接觸者,347名進行14天的主動追蹤,其中152名社區接觸者,195名醫療人員。在所有追蹤接觸者中,43名出現症狀成為疑似個案。這43名疑似個案及32名無症狀醫療人員病毒檢測皆為陰性。武漢肺炎人與人間的傳染發生在長時間且無保護的狀況下;除此之外,無進一步的傳染發生。

(由於新冠肺炎的致病機轉、傳播途徑、有效治療方式等尚待更多臨床與流行病學資料確定,請讀者自行參考文獻,以確保獲取最即時的科學性證據)

(財團法人國家衛生研究院 莊淑鈞博士摘要整理)

Background
Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first detected in China in December, 2019. In January, 2020, state, local, and federal public health agencies investigated the first case of COVID-19 in Illinois, USA.
Methods
Patients with confirmed COVID-19 were defined as those with a positive SARS-CoV-2 test. Contacts were people with exposure to a patient with COVID-19 on or after the patient’s symptom onset date. Contacts underwent active symptom monitoring for 14 days following their last exposure. Contacts who developed fever, cough, or shortness of breath became persons under investigation and were tested for SARS-CoV-2. A convenience sample of 32 asymptomatic health-care personnel contacts were also tested.
Findings
Patient 1—a woman in her 60s—returned from China in mid-January, 2020. One week later, she was hospitalised with pneumonia and tested positive for SARS-CoV-2. Her husband (Patient 2) did not travel but had frequent close contact with his wife. He was admitted 8 days later and tested positive for SARS-CoV-2. Overall, 372 contacts of both cases were identified; 347 underwent active symptom monitoring, including 152 community contacts and 195 health-care personnel. Of monitored contacts, 43 became persons under investigation, in addition to Patient 2. These 43 persons under investigation and all 32 asymptomatic health-care personnel tested negative for SARS-CoV-2.
Interpretation
Person-to-person transmission of SARS-CoV-2 occurred between two people with prolonged, unprotected exposure while Patient 1 was symptomatic. Despite active symptom monitoring and testing of symptomatic and some asymptomatic contacts, no further transmission was detected.
Funding
None.

Author:Isaac Ghinai MBBS, Tristan D McPherson, Jennifer C Hunter, et al.
原文連結:https://www.sciencedirect.com/science/article/pii/S0140673620306073?via%3Dihub