一名武漢肺炎住院病患及3名居家隔離病患於治療完成解除隔離後，RT-PCR檢查再度呈現陽性反應。本研究經武漢大學中南醫院IRB核准且不需病患同意函。本研究解除隔離條件為：1)正常體溫持續三天以上，2)呼吸道症狀緩解，3) chest CT急性病變明顯改善，4)連續兩次，間隔一天，咽喉檢體，RT-PCR檢測陰性。研究結果顯示，至少一部份康復病患仍為病毒帶原者。
Previous studies on coronavirus disease 2019 (COVID-19) mainly focused on epidemiological, clinical, and radiological features of patients with confirmed infection.1–4 Little attention has been paid to the follow-up of recovered patients.
One hospitalized patient and 3 patients (all medical personnel) quarantined at home with COVID-19 were treated at Zhongnan Hospital of Wuhan University, Wuhan, China, from January 1, 2020, to February 15, 2020, and evaluated with real-time reverse transcriptase–polymerase chain reaction (RT-PCR) tests for COVID-19 nucleic acid to determine if they could return to work. All the following criteria5 had to be met for hospital discharge or discontinuation of quarantine: (1) normal temperature lasting longer than 3 days, (2) resolved respiratory symptoms, (3) substantially improved acute exudative lesions on chest computed tomography (CT) images, and (4) 2 consecutively negative RT-PCR test results separated by at least 1 day.
The RT-PCR tests were performed on throat swabs following a previously described method.1 The RT-PCR test kits (BioGerm) were recommended by the Chinese Center for Disease Control and Prevention. The same technician and brand of test kit was used for all RT-PCR testing reported; both internal controls and negative controls were routinely performed with each batch of tests.
Demographic information, laboratory findings, and radiological features were collected from electronic medical records. After recovery, patients and their families were contacted directly, and patients were asked to visit the hospital to collect throat swabs for the RT-PCR tests.
This study was approved by the Zhongnan Hospital of Wuhan University institutional review board and the need for informed consent was waived.
Author：Lan Lan, Dan Xu, Guangming Ye, et al.